CPHON Chemotherapy Practice Test

These questions are part of the practice quiz. Start practicing

• Where do B cells mature?
• Peripheral neuropathy is usually:
• Bleomycin is notably associated with toxicity to which organ system?
• Which of the following is given to prevent hypersensitivity reactions?
• Which of the following is a characteristic of malignant cells?
• During the administration of etoposide, the patient should be closely monitored for:
• Meghan, a 7-year-old with a brain tumor, recently received cisplatin and has ongoing nausea and vomiting five days later. Which statement is most likely true?
• How does weight measurement influence chemotherapy dosing in pediatric patients?
• Chemo for osteogenic sarcoma can be administered by which route?
• During the inflammatory stage of an infection, the first granulocyte to arrive at the site of inflammation is the?
• In case of suspected chemotherapy overdose, which sequence is appropriate?
• Which administration route is used to deliver chemotherapy to treat central nervous system disease?
• Which presenting sign is most characteristic of neuroblastoma in a child?
• What two organs are closely monitored when a patient is receiving high dose methotrexate?
• What is the most common route for initial chemotherapy administration in pediatric oncology, and why is it preferred?
• What electrolyte disturbances characterize tumor lysis syndrome?
• What is a key reason for obtaining informed consent in a clinical trial?
• You are giving Doxorubicin peripherally IV push and based on the patient's complaints and loss of blood return, you suspect that the Doxorubicin has extravasated. Your immediate nursing intervention will involve:
• Which statement about methotrexate and pulmonary toxicity is true?
• Which symptom is least typical as a presenting sign of childhood leukemia?
• Which agent is a cell-cycle specific antimetabolite?
• Which statement best describes a cell cycle–specific chemotherapeutic agent?
• Progressive disease is defined as greater than what percentage increase in tumor burden or appearance of a new tumor?
• ANC is typically expressed in which unit?
• Which toxicities are commonly associated with L‑asparaginase and warrant monitoring?
• In a Phase I trial, what must be verified first before administering the investigational agent?
• Which statement best describes the typical pattern of chemotherapy-induced peripheral neuropathy?
• Important lab values to check prior to the administration of asparaginase include platelets and:
• Why is mesna given with ifosfamide therapy?
• Which body is primarily responsible for approving clinical trial protocols to protect human subjects?
• What preventive measure reduces bladder toxicity with cyclophosphamide?
• Which document approves research involving human subjects?
• Pharmacogenetics studies inherited differences in metabolism and effect; which option best describes this concept?
• Chemo-approved gloves are not required when which activity?
• Which of the following represents the Belmont Report’s ethical principle related to ensuring participants' protection and rights?
• In pediatric chemotherapy care, what is the purpose of involving a dietitian?
• Carboplatin dosing using the Calvert formula includes which parameter?
• Which statement is correct regarding daunorubicin and cardiotoxicity?
• Via which route is vincristine given?
• Which is most effective distraction technique to reduce pain during pediatric subcutaneous injections?
• Which practice best prevents chemotherapy dosing errors?
• What is the role of hand hygiene and PPE in preventing hospital-acquired infections for immunocompromised pediatric patients?
• Which statement regarding tumor markers in childhood cancers is true?
• To minimize the risk of pulmonary toxicity from bleomycin, what is the recommended approach to oxygen exposure?
• To perform clinical trials, researchers must be compliant with federal guidelines established by the FDA. The guidelines require that all research be approved by:
• Which test is used to assess hearing when there is a concern for ototoxicity from cisplatin therapy?
• What is the importance of assent and consent in pediatric chemotherapy treatment?
• A child with symptoms of SIADH is most likely to present with which electrolyte abnormality?
• In a Phase I clinical trial, which outcome is primarily evaluated to determine safety?
• Which factor increases the risk of cardiotoxicity with doxorubicin therapy?
• Carboplatin dosing using the Calvert formula requires monitoring which parameter as part of protocol?
• During high-dose methotrexate therapy, which laboratory and organ-function tests are essential to monitor?
• Which statement about cumulative dosing in chemotherapy is correct?
• Which electrolyte abnormality is characteristic of tumor lysis syndrome?
• Which statement best describes protocol compliance in clinical trials?
• Cisplatin carries a well-known risk of ototoxicity, which is commonly monitored with baseline audiometry.
• Which route is used to deliver chemotherapy directly into the central nervous system to treat brain tumors?
• Which scale is commonly used to grade mucositis severity in pediatric patients?
• Which statement best describes late effects of cancer therapy?
• For patients receiving bleomycin, which complication is most likely?
• Which statement accurately describes intrathecal administration in this context?
• Which statement about TLS prophylaxis is correct?
• What urine output rate is targeted to help prevent methotrexate-related nephrotoxicity?
• Which chemotherapy agent is associated with mucositis as a potential reaction?
• Which statement best defines histocompatibility leukocyte antigens (HLA)?
• Which TLS management agent rapidly lowers uric acid levels and requires consideration of G6PD deficiency when used?
• How should a pediatric oncology nurse respond to a suspected chemotherapy overdose?
• What are the key cardiac safety considerations with anthracyclines like doxorubicin?
• Which immunoglobulin causes secretion of histamines, leukotrienes and prostaglandins during a hypersensitivity reaction?
• Vincristine toxicity most commonly affects which body system?
• Which vaccine considerations are important for pediatric patients undergoing chemotherapy?
• Among vinca alkaloids, which is more likely to cause severe bone marrow suppression?
• Before a patient is to receive intrathecal chemotherapy, which precaution is essential?
• In assessing adherence, which statement is true?
• In TLS prevention, which uric acid–lowering therapy rapidly reduces uric acid levels and is used in high‑risk patients?
• Which of the following is a core ethical principle addressed by the Belmont Report?
• Mercaptopurine is classified as which type of chemotherapeutic agent?
• Which of the following is NOT part of the pre-asparaginase lab panel described?
• A 2-year-old receiving Vincristine shows signs of peripheral neuropathy. Which symptoms may indicate this side effect?
• Which PPE configuration is considered optimal during chemotherapy administration and when handling bodily fluids?
• Which Belmont Report principle emphasizes informed consent and treating individuals as autonomous agents?
• Capillary leak syndrome is most likely to develop following the administration of which agent?
• Which agent is used to prevent hemorrhagic cystitis when administering cyclophosphamide?
• Doxorubicin must be given within what timeframe relative to the start of the dexrazoxane infusion?
• Which class of chemotherapy agents includes drugs for which cumulative dose monitoring is especially important due to cardiotoxicity risk?
• During high-dose methotrexate therapy, which medication should be discontinued?
• Which chemotherapy-related mucositis care strategy is most effective for children?
• Which option correctly identifies a safety measure to prevent chemotherapy dosing errors?
• In phase I trials, which objective is typically sought?
• What are typical platelet transfusion thresholds in a stable pediatric chemotherapy patient?
• How is pharmacokinetics defined?
• What is a major safety concern with vincristine administration and what explicit precaution is required?
• Which intervention would be LEAST appropriate when supporting hospitalized young adults?
• Protective gloves should be discarded after how many minutes of wear?
• Which is the correct sequence of phases as the cell enters the cell cycle?
• Which of the following is an incorrect statement when providing information to caregivers regarding administering chemo in the home?
• What role does nutrition play in pediatric chemotherapy patient outcomes?
• Which of the following is a cell-cycle specific chemotherapy agent?
• If a nurse is administering IV chemotherapy and the IV line leaks, who is responsible for containing the spill?
• What is the primary purpose of intrathecal chemotherapy in pediatric patients?
• The immediate temperature application for a Doxorubicin/Daunorubicin extravasation involves:
• Which of the following is listed as a common route of exposure to chemotherapy agents?
• Which chemo agent is commonly associated with hemorrhagic cystitis?
• Baseline studies for children receiving anthracyclines should include:
• In phase III cancer trials, what is the primary objective?
• After administering the first drug for a dermatologic reaction after peg-Asparaginase, Sam starts to complain of throat tightening and he starts wheezing. The MD orders Epinephrine. What is the preferred route?
• John is a 3-year-old who is scheduled to receive his first subQ injection of Neupogen. What would NOT be an appropriate strategy to decrease the pain associated with a SC injection?
• Before administering vincristine, which nursing assessment is essential to monitor for potential neurotoxicity?
• What is the major neurotoxic effect of vincristine in pediatric patients and how should it be assessed?
• How is the absolute neutrophil count (ANC) calculated?
• Which of the following is a commonly observed adverse reaction that occurs during a rituximab infusion?
• Which statement best describes the earliest skin reaction associated with initial radiation therapy dosing?
• Which formula is most commonly used to calculate a child’s body surface area (BSA) for dosing?
• When is growth factor (G‑CSF) support generally considered in pediatric chemotherapy?
• Which agent commonly causes transient early diarrhea?
• Intrathecal methotrexate in pediatric leukemia is used for what purpose, and what is key about dosing?
• Which statement best describes the primary goal of phase II clinical trials in oncology when evaluating a new agent?
• Which plays a pivotal role in the body's lymphocyte immune response?
• Early therapeutic doses of radiation were chosen based on the skin reaction expected. Which outcome was used to estimate those doses?
• Which drug has notable cardiotoxic potential that necessitates a baseline echocardiogram before use?
• Which Belmont Report principle focuses on fairness in distributing research burdens and benefits?
• Rituximab is directed against which antigen?
• Which is the most appropriate safe-handling practice when caring for a child who received chemo within the last 24 hours?
• In high‑dose methotrexate therapy, when should leucovorin rescue begin and for how long should it continue?
• What is the rationale for limiting lifetime cumulative doxorubicin exposure and how is it monitored?
• What special consideration is required before using rasburicase in TLS?
• Which action is NOT an immediate intervention for doxorubicin extravasation?
• Progressive disease (PD) is defined as?
• Which combination of electrolyte disturbances is most characteristic of tumor lysis syndrome?
• Allopurinol functions in TLS prevention by inhibiting xanthine oxidase to reduce uric acid production. Which statement is true?
• In high-dose methotrexate therapy, leucovorin rescue is used to restore healthy cells. Which option best describes this purpose?
• Which statement best describes assent in pediatric chemotherapy?
• In febrile neutropenia management, under what condition is patient isolation typically implemented?
• Which Chemo agent is associated with a high risk for hypersensitivity reaction?
• What is the recommended practice for flushing and maintaining a central venous catheter during chemotherapy?
• What is tumor lysis syndrome and what are the key preventive measures in a high‑risk child receiving chemotherapy?
• Which chemotherapy agent is most commonly associated with hypomagnesemia?
• Which of the following is a red flag that would prompt a red blood cell transfusion in a pediatric chemo patient?
• In anaphylaxis due to peg-Asparaginase, what is the preferred route for epinephrine administration?
• Which statement best describes the nursing assessment for patency with a direct-push method of administering a chemotherapy vesicant?
• Which oral preparation contains aspartame and should be used with caution in children with phenylketonuria?
• In pediatric oncology, what are the core steps in managing febrile neutropenia?
• Based on Kayla's case of a brain tumor treated with surgery, chemotherapy, and radiation, which statement is most accurate?
• Which antiemetic combination is commonly used for pediatric chemotherapy‑induced nausea and vomiting?
• Which federal agency requires health care facilities to maintain policies for the safe handling of chemotherapy agents?
• Risk factors that may influence the development of late effects include all of the following except:
• What is the immediate management for suspected vesicant extravasation of a chemotherapy drug?
• Which oncogene is commonly amplified in neuroblastoma?
• Intrathecal chemotherapy dosage is based on which parameter?
• Cancer treatment may also cause secondary malignant neoplasms. Which agent has been linked to later development of Acute Myeloid Leukemia (AML) and myelodysplastic syndrome (MDS)?
• Pharmacogenetics refers to the:
• Which parameter is essential to monitor hydration status during high-dose methotrexate therapy?
• Which statement about late effects of chemotherapy is true?
• Which of the following is a common adverse reaction during a rituximab infusion?
• While hanging an IV chemo bag, the bag disconnects and spills; what is your first action?
• A Nuremberg Code was the first document written to address:
• PPE is not required in which scenario?
• A strategy to prevent chemo errors includes:
• Which of the following is a common side effect caused by vincristine?
• Which agent is commonly associated with transient diarrhea in chemotherapy?
• Which monitoring parameter is commonly checked to detect pancreatitis risk during L‑asparaginase therapy?
• How should imatinib be taken for optimal absorption?
• Which route is used to deliver chemotherapy directly into the cerebrospinal fluid?
• Which statement best describes what a vesicant is?
• Which baseline assessment is commonly performed before starting chemotherapy in a pediatric patient?
• What steps ensure safe drug administration for immunocompromised pediatric patients during hospitalization?
• Which chemo agent causes delayed nausea and vomiting?
• L-Asparaginase is classified as which type of agent?
• Which of the following is a potential reaction to cytarabine?
• Which drug is a classic antimetabolite used in leukemia treatment?
• It is important to monitor for late effects following chemo. After receiving Cisplatin, which body system will need to be monitored?
• During high-dose methotrexate therapy, which organ pairs are monitored for toxicity?
• Compare the principal toxicities of cisplatin and carboplatin.
• Which trio of ethical principles comprises the Belmont Report?
• What central venous access device is commonly used for long‑term pediatric chemotherapy to facilitate frequent dosing and vesicant administration?
• The preferred intramuscular site for a child who is three-years-old and walks is:
• Which chemo agent is associated with a maximum cumulative lifetime dose?
• Which blood cell type, when decreased, is associated with increased infection risk?
• The initial action in the event of accidental eye contact with a cytotoxic agent is:
• Which of the following is a monoclonal antibody used in cancer therapy?
• Prior to starting multimodal chemotherapy for osteosarcoma, which diagnostic test is NOT routinely indicated to establish baseline organ function?
• Which diagnostic test would you order prior to daunorubicin administration to assess cardiac function?
• Which infusion is titrated up to achieve the prescribed dose?
• What is the purpose of informed consent in a clinical trial?
• Chemo administered to treat CNS disease is delivered via which route?
• Most monoclonal antibodies used in therapy target which class of immunoglobulins?
• Rituximab binds to the CD20 antigen on B cells. Which cell type is primarily affected?
• What is the first essential step in handling a chemotherapy spill?
• How should chemotherapy dosing be adjusted in a patient with significant renal or hepatic impairment?
• TLS prophylaxis aims to prevent which complication?
• Which of the following is a basic required element in the informed consent document?
• Cumulative dose of which class of chemotherapy agents should be monitored?
• Which of the following is NOT a basic required element in informed consent?
• Why is TPMT testing important before starting 6‑mercaptopurine in pediatric oncology?
• The goal of a phase I clinical trial is to determine:
• Which statement is true regarding initial signs and symptoms of childhood cancer?
• How should mercaptopurine dosing be adjusted in a patient with TPMT deficiency?
• Which of the following is the most important practice to prevent exposure to health care workers?
• During the 1970s, which type of therapy was found to improve response rates and survival without significantly increasing toxicity?
• What is a major pulmonary toxicity associated with bleomycin, and what monitoring is recommended?
• Which intervention is appropriate for a patient receiving thiotepa?
• Nursing care priorities for the child with symptoms of SIADH include:
• Which measure is essential to promote clearance of methotrexate during high-dose therapy?
• Which statement best defines late effects in the context of cancer therapy?
• Which group evaluates all clinical trials in relation to human subject protections?
• In suspected tumor lysis syndrome, which IV fluid strategy is anticipated to support renal excretion of metabolites?
• For high-emetogenic risk regimens, which antiemetic addition may be used beyond ondansetron and dexamethasone?
• Which pairing of chemotherapy agent and monitoring is correct?
• Which statement describes rituximab infusion dosing?